约翰霍普金斯大学医学院神经系招聘博士后

  约翰霍普金斯大学医学院神经系招聘博士后,以下是厚谱教育为您收集整理的博士后招聘信息。

  Department of Neurology at the Johns Hopkins University School of Medicine.

  Bi-directional communication between glia and neurons regulates synaptic formation, synaptic strength, and participates in the regulation of neural circuitry by coordinating activity among groups of neurons. A chronic low level neuroinflammation associated with aging, Alzheimer's and other neurodegenerative conditions has been postulated to disrupt the activity of neural networks involved in memory and executive functions. However, the precise mechanisms by which a chronic low level inflammation damages neural circuits has been elusive. Advancements in our understanding of the biology of extracellular vesicles have begun to implicate glial released extracellular vesicles as primary mediators of glia to neuron communication. Extracellular vesicles are nanoparticles containing protein, lipid and miRNA cargo that are shed from cells in a constitutive and stimulus dependent manner. Very little is currently known about these particles in the central nervous system, and interest is rapidly expanding to understand their biology, how these systems are perturbed by disease and if they can be manipulated in a therapeutic manner. The goals of this project are to understand how endogenous excitatory stimuli and inflammatory stimuli modify the protein, miRNA and metabolite cargo of glial-shed exosomes, and to determine the molecular mechanisms by which glial (astrocyte and microglia) shed exosomes regulate/dysregulate the structure and function of target neurons. We are particularly interested in understanding roles for exosomes in regulating protein trafficking/function, endosomal/lysosomal activity, energy metabolism, plasticity, survival, and innate immune function. We are looking for a postdoctoral fellow with not more than 2 years postdoctoral training and strong background in immunology, or neuroscience. We are seeking a highly motivated individual who can provide intellectual input, project leadership, and can also work well within a group.

  约翰霍普金斯大学由1876年威廉·奥萨爵士创办。又名威廉·奥斯拉爵士。

  1871年春天,一个年轻人,作为一名蒙特瑞综合医院的医科学生,他的生活中充满了忧虑:怎样才能通过期末考试?该做些什么事情?该到什么地方去?怎样才能开业?怎样才能谋生?他拿起一本书,看到了对他的前途有着很大影响的24个字。

  这24个字使1871年这位年轻的医科学生成为当时最著名的医学家。他创建了闻名全球的约翰·霍普金斯医学院,成为牛津大学医学院的钦定讲座教授--这是大英帝国医学界所能得到的最高荣誉--你还被英王封为爵士。死后,记述他一生经历的两大卷书,原书达1466页。

  他就是威廉·奥斯勒爵士。1871年春天他所看到的那24个字帮助他度过了无忧无虑的一生。这24个字就是:"最重要的是不要去看远处模糊的,而要去做手边清楚的事。"是汤姆斯·卡莱里所写的。

  约翰霍普金斯大学以医科驰名于世,为美国现代医学圣地。该校所有跟生物沾亲带故的专业,都在美国名声斐然,其中包括生物医学工程、化学和生物化学等。大学的医院是学生们搞临床研究的好去处,约翰·霍普金斯医院几乎年年被医学杂志评为最好的医院。其它科目如英语、历史、美术、国际关系、政治科学、政治经济十分出色。其它学科文、理、工也相当不错。

  与约翰霍普金斯大学有关的诺贝尔奖得主有36位。4位教授荣获过国家科学奖章。